Gastro Protective Effects of Tadalafil on Ethanol- induced and Reserpine –induced Gastric Ulcer in Rats
Published: 2022-03-25
Page: 38-44
Issue: 2022 - Volume 5 [Issue 1]
Doris N. Ajibo *
Department of Experimental Pharmacology and Toxicology, Faculty of Pharmacy, University of Port Harcourt, PMB 5323, Choba, Rivers State, Nigeria.
Udeme O. Georgewill
Department of Pharmacology, Faculty of Basic Clinical Sciences, University of Port Harcourt, PMB 5323, Choba, Rivers State, Nigeria.
Owunari A. Georgewill
Department of Pharmacology, Faculty of Basic Clinical Sciences, University of Port Harcourt, PMB 5323, Choba, Rivers State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Background: Drug repurposing is a system whereby drugs already in use are redirected for another therapeutic use. Tadalafil is PDE5 inhibitors. This research study investigated the potential of tadalafil which is used in the management of erectile dysfunction on ethanol- induced and reserpine –induced gastric ulcer in rats.
Method: Cialis® which contain 20mg of tadalafil was used. Male rats weighing 180 -252g were orally administered 95% Ethanol at 1ml/200g of rats to induce gastric ulcer at 1h post tadalafil administration. In another group, 5mg/ml of Reserpine in 0.5% acetic acid was administered to rats to induce gastric ulcer, also at 1h post tadalafil administration. Omeprazole was used as standard drugs. After 4h, stomach tissues were removed and assessed for Ulcer Index and Protective ratio. Result: 50mg/kg of tadalafil exhibited a significant reduction in Ulcer Index in reserpine-induced and ethanol-induced models when compared to standard.
Conclusion: Tadalafil has gastro protective potential at lower concentration.
Keywords: Gastric ulcer, tadalafil, ethanol, wistar rats